Blog, News and Events

31 March 2026

Primary Human Hepatocytes drive Advances in New Approach Methodologies

New approach methodologies (NAMs) are innovative, non-animal scientific methods used for testing chemical safety, drug development and biological research. In 2025, the FDA announced a new initiative to phase out animal testing for certain types of drug development1. This has led to renewed interest in NAMs and their role in pre-clinical drug development. NAMs include advanced in vitro models such as co-culture models, organ on a chip, 3D bioprinting and tissue models and Microphysiological systems (MPS)

Blog, PXB-cells

24 March 2026

DILI modeling using primary human hepatocytes (PXB-cells)

Hepatocytes form bile canaliculi structures which are formed through tight-junction interactions between neighboring hepatocytes. This interconnected network collects and transports bile components. Interruptions to the bile flow (slowing or stopping) causes a backup of bile and is known as cholestasis. Cholestasis can be a result of intrahepatic complications, including chronic liver disease, cirrhosis, hepatitis, infections, genetic cholestasis, as well as a result from drug-induced liver-injury (DILI).

Blog, PXB-cells

11 March 2026

Exploring the Human Lipoprotein Profile of PXB-mice and PXB-cells

Lipids are important biomolecules that contribute to homeostasis. They can act as energy reserves, are used structurally, and play an important role in metabolic processes including drug metabolism. Lipids complex with proteins resulting in a lipoprotein particle that enables the hydrophobic lipids to be transported throughout the body via the blood stream. Changes in the lipoprotein/lipid profile are associated with diseases such as metabolic dysfunction-associated fatty liver disease (MAFLD), atherosclerosis, hypothyroidism, and cardiovascular disease as well as some genetic disorders. As such, therapeutics are being developed to target dyslipidemia.

PXB-mouse, Blog, PXB-cells

27 February 2026

Translational liver disease models designed to suit your research needs

At PhoenixBio, we strive to help improve human health through the broad application of our humanized liver chimeric mouse model, the PXB-mouse. Our chimeric mouse model has a highly humanized liver, with human-specific metabolism pathways and gene expression as well as human-like lipid profiles, making this a relevant model for drug discovery and development projects. While we commercially produce PXB-mice using a single human hepatocyte donor lot, we understand that some research may require different hepatocyte donors, such as donors with specific characteristics (HLA typing or disease state) or even donors from different species (NHPs, humans, or others). Therefore, we offer custom transplantation services with our host mouse (cDNA-uPA/SCID background) which allows researchers to select and test engraftment of a hepatocyte donor that meet their specific research needs. First, we will highlight research that used a hepatocyte donor transplanted by our expert team into host animals for a rare genetic disease, Ornithine Transcarbamylase Deficiency (OTCD).

PXB-mouse, Blog

1 December 2025

Cryopreserved PXB-cells: enhance in vitro drug development with quality primary human hepatocytes

Late-stage drug failures remain a significant challenge in the clinical development process, resulting in financial losses and wasted resources. That’s why having a reliable, physiologically relevant in vitro model is crucial for building confidence in a therapeutic candidate before progressing to in vivo and clinical studies.

Blog, PXB-cells

23 September 2025

PhoenixBio is Heading to ISSX 2025. Join Us in Chicago!

We’re thrilled to announce that PhoenixBio will be exhibiting at ISSX 2025, the 25th International Meeting of the International Society for the Study of Xenobiotics. We can’t wait to engage with researchers, industry leaders, and innovators in xenobiotic science from around the globe. We'll be sponsoring a booth and attending ISSX 2025 in person at the Hilton Chicago in Chicago, Illinois from September 21st - 24th, 2025. Meet with our team at Booth #219 to learn more about PhoenixBio's capabilities and how we can help you advance and deliver tomorrow’s technologies.

Events

15 September 2025

Exhibition at EuroTox 2025

The Congress of the European Societies of Toxicology is organizing EuroTox 2025 to focus on this year's theme “Toxicology addresses Society’s real-life risks for sustainable health and well-being”. The 2025 program will focus on cutting-edge scientific breakthroughs and interdisciplinary collaboration. Emerging technologies and methodologies such as humanized liver applications in toxicology will be highlighted, while fostering discussions on public health safety and environmental sustainability. PhoenixBio is excited to be sponsoring a booth and attending the EuroTox 2025 in person at the Megaron Concert Hall in Athens, Greece from September 14th - 17th, 2025. Meet with our team at Booth #A17 to learn more about PhoenixBio's capabilities and how we can help you advance and deliver tomorrow’s technologies.

Events

11 September 2025

Cutting Edge Gene Editing in Primary Human Hepatocytes

Gene editing promises cures for a wide range of diseases. Zinc-finger nucleases (ZFNs) were developed as the first programmable editors in the early 2000s, followed by TALENs (Transcription Activator Like Effector Nucleases) about a decade later[1]. However, it was the discovery and application of easy to use CRISPR/Cas9 gene editing methods, that sparked a flurry of new activity since 2013. New gene editing methods that build on this platform continue to be a hot area of research, with the goal of developing techniques that increase specificity and circumvent the need for double-stranded breaks (DBSs) in order to reduce off-target effects and minimize safety concerns[2]. Moreover, increasing the size of sequences that can be modified, and improving editing efficiency in non-dividing cells are also areas of great interest.

Blog, PXB-cells