Blog, News and Events

18 August 2025

Bridging the translational gap: Humanized Liver models as predictive tools for RNA therapeutic success

Introduction The field of RNA therapeutics, with its potential for treating a wide range of diseases, continues to experience rapid growth and attracts significant investment. According to the American Society of Gene & Cell Therapy (ASGCT), as of Q1 2025, 35 RNA therapies have been approved globally and another 1,298 are currently in development (between preclinical and pre-registration stages) [1].

PXB-mouse, Blog

17 June 2025

From modeling disease to supporting translational preclinical studies: a year in humanized liver model research

PXB-mice and PXB-cells offer a highly physiologically relevant liver model for in vivo and in vitro research, respectively. They have been shown to have versatile applications in studies, ranging from hepatitis B virus (HBV) infection modeling to epigenetic research. In this round-up, we look back on the past year to showcase some of the most interesting and impactful research utilizing PXB-mice and/or PXB-cells, spanning disease modeling, drug metabolism, and epigenetic editing.

Blog

10 June 2025

Exhibition at the MPS World Summit 2025

PhoenixBio is excited to be sponsoring a booth and attending the Microphysiological Systems World Summit 2025 (MPS 2025) in person in Brussels, Belgium from June 10th - 13th, 2025. Meet with our team at Booth #110 to learn more about PhoenixBio's capabilities and how we can help you improve lives through tomorrow's technologies.

Events

12 May 2025

Exhibition at the American Society of Cell & Gene Therapy 2025 Meeting

PhoenixBio is excited to be sponsoring a booth and attending the American Society for Gene & Cell Therapy (ASGCT 2025) in person in New Orleans, USA from May 13th - 17th, 2025. Meet with our team at Booth #1444 to learn more about PhoenixBio's capabilities and how we can help you improve lives through safe and effective cell and gene therapies.

Events

7 May 2025

Exhibition at the ISCT 2025

PhoenixBio is excited to be sponsoring a booth and attending the International Society for Cell & Gene Therapy (ISCT 2025) in person in New Orleans, USA from May 7th - 10th, 2025. Meet with our team at Booth #223 to learn more about PhoenixBio's capabilities and how we can help you improve lives through safe and effective cell and gene therapies.

Events

1 May 2025

Exhibition at the EASL Congress 2025

PhoenixBio is excited to be sponsoring a booth and attending the EASL Congress 2025 in person in Amsterdam, the Netherlands from May 7th - 10th, 2025. Meet with our team at Booth #BS24 to learn more about PhoenixBio's capabilities and how we can help you advance and deliver tomorrow’s technologies.

Events

19 December 2024

Humanized Liver Models: Revolutionizing RNA Therapeutic Development

The rapid growth of RNA therapeutics, including siRNA and mRNA, is transforming the pharmaceutical and medical landscape, offering unprecedented potential for treating diseases ranging from viral infections to metabolic disorders. Despite this promise, translating these groundbreaking treatments from the lab to the clinic is fraught with challenges.

PXB-mouse, News, Blog

9 December 2024

Targeting cccDNA in Human Hepatocytes: Pathway to a Cure for HBV?

Globally, around 250 million people are infected with hepatitis B virus (HBV) and more than 1 million more are estimated to become infected yearly. Researching the HBV viral life cycle and identifying potential novel therapeutics is challenging as only human and chimpanzee hepatocytes are permissive to HBV. However, due to the cost and ethical restrictions, alternative models are being explored. In vivo, rodent models including humanized liver chimeric mice (for example PXB-mice) and the AAV-HBV mouse model are being utilized. While these models are useful, each has their own pitfalls.

Blog, PXB-cells