Methylmalonic acidemia (MMA) is a rare genetic disorder most commonly caused by mutations in the gene encoding mitochondrial methylmalonyl-CoA mutase, MMUT. MMA patients suffer from frequent episodes of metabolic instability, leading to developmental delay and other neurological abnormalities and are potentially lethal. There is no cure for MMA; the current standard of care mainly consists of a highly restricted diet. However, even under strict dietary management, many patients remain metabolically unstable, and liver transplantation becomes the only therapeutic alternative for these patients