• Inhibition of the acetyl-coenzyme A (CoA) carboxylase (ACC) isoforms ACC1 and ACC2 reduces lipogenesis, stimulates lipid oxidation, and improves histologic features and fibrosis-related biomarkers in nonalcoholic steatohepatitis (NASH)
  • Obeticholic acid (OCA), a farnesoid X receptor agonist, reduces bile-acid synthesis and regulates lipid metabolism in the liver

Authors: David Hollenback, Wen-Wei Tsai, Andrew Schwab, Megan Showalter, James L. Trevaskis

See poster

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